How the Cannabinoid receptors interact with the human body?

Cannabinoid receptors are located throughout the body, they are part of the endocannabinoid system (described in the previous article here https://link.medium.com/riwNgU5h4S), which is involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory.

The best known subtypes of cannabinoid receptors are called CB1and CB2. The CB1 receptor is expressed mainly in the brain (central nervous system), but also in the lungs, liver and kidneys. The CB2 receptor is expressed mainly in the immune system and in hematopoietic cells.

They are also found in other parts of the body. For instance, in the liver, activation of the CB1 receptor is known to increase thelipogenesis process.

The CB2 receptors are mainly expressed on T cells of the immune system, on macrophages and B cells, and in hematopoietic cells. They have a function in keratinocytes and they are presenton peripheral nerve terminals. These receptors play a role in the relief of pain.

Cannabinoid receptors are activated by cannabinoids, generated naturally inside the body (endocannabinoids) or introduced into the body as cannabis or a related synthetic compound. After the receptor is engaged, multiple intracellularsignal transduction pathways are activated. All of the endocannabinoids and phytocannabinoids (plant based cannabinoids like hemp, cannabis and hop) are lipophilic, such as fat soluble compounds.

While the most likely cellular targets and executors of the CB2 receptor-mediated effects of endocannabinoids or synthetic agonists are the immune and immune-derived cells (e.g. leukocytes, various populations of T and B lymphocytes, monocytes/macrophages, dendritic cells, mast cells, microglia in the brain, Kupffer cells in the liver, astrocytes, etc.), the number of other potential cellular targets is expanding, now including endothelial and smooth muscle cells, fibroblasts of various origins, cardiomyocytes, and certain neuronal elements of the peripheral and central nervous systems.

The cannabinoids receptor are carry on inside the G protein-coupled receptors (GPCR), they are a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. The G proteins are called seven-transmembrane receptors because they pass through the cell membrane seven time.

GPCRs are involved in a wide variety of physiological processes. Some examples of their physiological roles include the interaction with the most important sensitive organs like visual, gustatory, olfactory, behavioral and mood regulation, immune and nervous system.

If the nature offers us the hemp plant with all this beneficial and healing properties, why not take advantage of this gift?

In the picture, the activity of the main receptors inside the human body.

If you have already tried any CBD or hemp derivatives products, which symptoms or diseases you are looking for strive and improve?which results are you reaching? give your opinion or any suggestion..



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