Nice article, – Andreas Spannbauer – Medium

Nice article,

though, Im not sure I understand your reasoning and your interpretation of your sources behind both claims:

> 1. Caffeine tends to interfere with the production of cortisol. Over the time, the body then produces less of the hormone and relies more on the caffeine (4).

The source you cite doesn’t say that. They looked into the physiological response of the cortisol system to caffeine (which is an *increase* in cortisol when caffeine is consumed) and whether an increase in caffeine dose diminishes this effect over time. They did find some development of tolerance in this regard but never a decrease below normal levels. In fact, if you look at the graph of cortisol concentration, the No-caffeine group has consistently *lower* levels of cortisol at all times than any of the caffeine groups. *This is the opposite of your conclusion*.

Next you say:

> Furthermore, caffeine consumption during peak hours of cortisol greatly diminishes caffeines effects.

You cite no source for this but it would make sense that when you are already awake through cortisol, blocking adenosine receptors wouldn’t do as much to further increase wakefulness, so I agree with your basic claim that timing your caffeine intake is important. I’m just not sure your biological explanation as to why that’s the case is correct.

> *Drinking coffee while cortisol levels are high leads you to develop long-term tolerances for caffeine*. Caffeine is a drug after all and a principle of chronopharmacology is that a drug should only be taken when needed or otherwise tolerance sets in and the effects stay out.

Do you have a source for this?

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