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The Senate is still working, well into August – something it hasn’t done in years — and it’s debating the funding…
Glucose metabolic reprogramming from oxidative phosphorylation to glycolysis is one of the hallmarks of cancer development. Coenzyme Q10 (CoQ10) is essential for electron transport in the mitochondrial respiratory chain and for antioxidant defense. Here, we investigated the role of…
Hotel Nacional – a long-abandoned Rio de Janeiro landmark designed by Oscar Niemeyer – has reopened as a luxury resort after a major overhaul.
The cylindrical tower rises up from the beachfront of Rio’s São Conrado neighborhood, just a short…
Pitaya commonly referred to as Dragon Fruit is considered one of nature’s most amazing creations. A member of the cactus species, the pitaya has a succulent stem, beautiful luminous flowers that give the impression of exploding flames and produces…
Unseen plans for Mies van der Rohe’s only London building – axed after a royal row – could come to light in a new publication.
Mansion House Square was designed by the Modernist architect in the 1960s. Despite 20 years…
Of all the indignities that come with aging, excessive earwax may be the most insidious.
That greasy, often gross, buildup occurs more often in older ears than those of the young, experts say. And when it goes unrecognized, it…
Of the three RAS oncoproteins, only HRAS is delocalized and inactivated by farnesyltransferase inhibitors (FTI), an approach yet to be exploited clinically. In this study, we treat mice bearing Hras-driven poorly differentiated and anaplastic thyroid cancers (Tpo-Cre/HrasG12V/p53flox/flox) with the…
Health care centres, high rises and even penguin pools; Berthold Lubetkin left an enduring legacy across London. But the Modernist architect’s own Highgate apartment is where he really shone.
Lubetkin designed the Highpoint housing complex for local entrepreneur Sigmund Gestetner….
In a surprising reversal, a Wisconsin board has voted to again offer insurance coverage to transgender state employees seeking hormone therapy and gender confirmation surgery.
Members of the Group Insurance Board, which manages the insurance program for Wisconsin’s public workers…
Mutated or dysregulated DDX3 participates in the progression and metastasis of cancer via its multiple roles in regulating gene expression and cellular signaling. Here, we show that the high expression levels of DDX3 in head and neck squamous cell…
Surgery is a mainstay of breast cancer treatment, offering most women a good chance of cure.
For frail nursing home residents, however, breast cancer surgery can harm their health and even hasten death, according to a study published Wednesday in…
The efficacy of T-cell therapy is inhibited by various tumor-associated immunosuppressive ligands and soluble factors. Such inhibitory signals turn specific T-cell signaling pathways on or off, impeding the anticancer functions of T cells. Many studies have focused on PD-1…
Photography: VSF. Courtesy of the Pritzker Architecture Prize
Indian architect Balkrishna Doshi has won the 2018 Pritzker Prize for architecture at the grand age of 90.
Doshi – a Le Corbusier disciple and a pioneer of low-cost, quality housing – is…
GacLife LLC has announced their official launch of the Gac drinkable skin and vision care supplement. Additionally, they look delicious.Supported by extensive scientific research and packed with 90 different healing compounds, GacLife developed an all-natural gac-infused functional beverage that…
The inspector general at the Department of Health and Human Services this month launched an examination into federal oversight of skilled nursing facilities amid signs some homes aren’t meeting Medicare’s minimum staffing requirements.
Look Up Nursing Homes In Your State
Cancer invasion and metastasis are driven by epithelial–mesenchymal transition (EMT), yet the exact mechanisms that account for EMT in clinical prostate cancer are not fully understood. Expression of N-cadherin is considered a hallmark of EMT in clinical prostate cancer….
In my life coaching practice, whenever I am able to help a client to understand presence, the entire conversation takes on a new shape. Suddenly, there is an anchor point to which the conversation can moor itself. A context can be…
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